What can make an unconfirmed transaction (0-conf) an invalid one other than Double-spend?

What can make an unconfirmed transaction (0-conf) an invalid one other than Double-spend?

It's obvious that inputs that already been spent will make the transaction invalid (pure double-spend scenario), but is there's anything else that could make a tx invalid?

Invalid inputs? Invalid signature or other data?

For example, if I have a program that manages a wallet (keypairs are exclusively managed by it, and not by any human, and it's source is public) and it sends payments, can the recipient be insured that even 0-conf tx will be eventually valid and processes?

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